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Side 196Side Studies / Research

Subject

Medicine

Purpose

Human disease and care studied through diagnosis, mechanism, intervention, prognosis, uncertainty and the integration of evidence with individual context.

Structure

05 movesMechanism mapV0

Entities → interactions → mechanisms → scales → measurement

01 · Model

Move from signs to decisions without pretending uncertainty disappears.

Medicine is a decision discipline built on biological knowledge but constrained by incomplete information, competing risks, patient values and variable treatment effects.

01

Presentation & problem representation

Compress symptoms, signs, history and context into a representation that preserves discriminating information without prematurely naming a diagnosis.

02

Differential diagnosis

Generate and rank plausible causes using prevalence, mechanism, severity and the expected value of further information.

03

Testing & updating

Treat tests as evidence that shifts probability rather than as binary truth machines, with sensitivity, specificity and pretest probability explicit.

04

Intervention & trade-offs

Compare benefits, harms, interactions, feasibility and patient preferences rather than optimizing one clinical endpoint in isolation.

05

Prognosis & follow-up

Update decisions over time as disease evolves, treatment response appears and new evidence changes the working model.

02 · Distinctions

Keep the boundaries visible.

These separations prevent nearby ideas from collapsing into one another before the subject is understood.

Do not conflate

diagnosis ≠ certainty

Do not conflate

statistical significance ≠ clinical importance

Do not conflate

guideline ≠ patient-specific command

03 · Questions

Questions that organize the Side.

Use these to test whether the model is becoming explanatory rather than merely familiar.

01

How should diagnostic probability change after a test result?

02

When is watchful waiting a better intervention than immediate treatment?

03

How should population evidence be adapted to a patient whose risks and values differ from the study average?

04 · Evidence

What should carry weight here?

Clinical claims should distinguish randomized evidence, observational evidence, diagnostic accuracy, mechanistic plausibility and expert consensus, with outcome relevance and absolute effects visible.